joints
Subjective joint comfort, 45 days
89% reported improved joint comfort
Eighty-nine subjects with joint discomfort ingested 2 g of BioCell Collagen daily for 45 days. Eighty subjects (89%) experienced improved joint comfort. One placebo subject improved. No adverse events associated with BioCell Collagen.
Human trial, 89 subjects
joints
Confirmatory WOMAC trial, 10 weeks
71% had at least 30% less discomfort
Randomized, double-blind, placebo-controlled trial in 80 subjects. 2 g daily for 10 weeks. Confirmed the earlier WOMAC result. No adverse events associated with BioCell Collagen.
Journal of Agricultural and Food Chemistry, 2012
skin
Facial aging, 12 weeks
Fewer lines, less dryness, more dermal collagen
Twenty-six subjects undergoing natural and photoaging took 1 g daily for 12 weeks. Measurements included wrinkles, fine lines, dermal collagen, hydration, and microcirculation. BioCell Collagen reduced facial lines and wrinkles, reduced dryness and scaling, and increased collagen content in the dermis. No adverse events.
Clinical Interventions in Aging, 2012
bioavailability
Hyaluronic acid bioavailability
Up to a 60-fold increase in steady-state HA
In a 36-hour single-dose study, HA in blood peaked more than 7000% above control at twelve hours. In a 28-day daily-dose study, steady-state HA reached about 3500% above control and an HA metabolite more than 11,000% above control. Subjects taking Liquid BioCell (1500 mg/day) for 28 days increased steady-state HA as much as 60-fold. The matrix also deactivates hyaluronidase, the enzyme that breaks HA down.
Judy, W. SIBR, 2004 · HA follow-on in Liquid BioCell